Article
Tumor endothelium marker-8 based decoys exhibit superiority over capillary morphogenesis protein-2 based decoys as anthrax toxin inhibitors.
PloS one - 1 Jan 2011
Cai Chenguang, Che Jinjing, Xu Long, Guo Qiang, Kong Yirong, Fu Ling, Xu Junjie, Cheng Yuanguo, Chen Wei
Abstract excerpt
Anthrax toxin is the major virulence factor produced by Bacillus anthracis. The toxin consists of three protein subunits: protective antigen (PA), lethal factor, and edema factor. Inhibition of PA binding to its receptors, tumor endothelium marker-8 (TEM8) and capillary morphogenesis protein-2 (CMG2) can effectively block anthrax intoxication, which is particularly valuable when the toxin has already been...
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