Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contribution of individual toxin components to virulence of Bacillus anthracis.

Infection and immunity - 1 Oct 1991

Pezard C, Berche P, Mock M

Abstract excerpt

Three proteins, protective antigen (PA), lethal factor (LF), and edema factor (EF; a calmodulin-dependent adenylate cyclase), compose the lethal (PA + LF) and edema (PA + EF) toxins secreted by Bacillus anthracis. Mutant strains, each deficient in the production of one toxin component, were constructed, and their virulence was then studied. A kanamycin resistance cassette was inserted in each cya (encoding EF)...

Topics

Animals
Antigens, Bacterial
Bacillus anthracis
Bacterial Toxins
Edema
Female
Lethal Dose 50
Mice
Mutation
Virulence

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 1910002
DOI: 10.1128/iai.59.10.3472-3477.1991
PMCID: PMC258908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1910002-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contribution of individual toxin components to virulence of Bacillus anthracis.PMID 1910002Read ↗

Differential contribution of Bacillus anthracis toxins to pathogenicity in two animal models.Semantic proximity Read ↗

Catalytically inactive anthrax toxin(s) are potential prophylactic agents.Semantic proximity Read ↗

Protective immunity induced by Bacillus anthracis toxin-deficient strains.Semantic proximity Read ↗

Certhrax Is an Antivirulence Factor for the Anthrax-Like Organism Bacillus cereus Strain G9241.Semantic proximity Read ↗

Contribution of lethal toxin and edema toxin to the pathogenesis of anthrax meningitis.Semantic proximity Read ↗

Direct Regulons of AtxA, the Master Virulence Regulator of Bacillus anthracisSemantic proximity Read ↗

Soluble expression and purification of the anthrax protective antigen in E. coli and identification of a novel dominant-negative mutant N435C.Semantic proximity Read ↗

Expression and contribution to virulence of each polysaccharide capsule of Bacillus cereus strain G9241.Semantic proximity Read ↗

[Bacillus anthracis: a molecular look at a famous pathogen].Semantic proximity Read ↗

Estimating the Relative Contributions of Virulence Factors for Pathogenic MicrobesSemantic proximity Read ↗

Vaccine protection against Bacillus cereus-mediated respiratory anthrax-like disease in mice.Semantic proximity Read ↗

Identification of new dominant-negative mutants of anthrax protective antigen using directed evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.