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Article

Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.

The New England journal of medicine - 2 Jun 2005

Rieder Mark J, Reiner Alexander P, Gage Brian F, Nickerson Deborah A, Eby Charles S, McLeod Howard L, Blough David K, Thummel Kenneth E, Veenstra David L, Rettie Allan E

Abstract excerpt

BACKGROUND: The management of warfarin therapy is complicated by a wide variation among patients in drug response. Variants in the gene encoding vitamin K epoxide reductase complex 1 (VKORC1) may affect the response to warfarin. METHODS: We conducted a retrospective study of European-American patients receiving long-term warfarin maintenance therapy. Multiple linear-regression analysis was used to determine the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15930419
DOI: 10.1056/NEJMoa044503

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.PMID 15930419Read ↗

<i>VKORC1</i> Polymorphisms, Haplotypes and Haplotype Groups on Warfarin Dose Among African–Americans and European–AmericansSemantic proximity Read ↗

Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1 - rationale and perspectives.Semantic proximity Read ↗

Association of Vitamin K epoxide reductase complex 1 (VKORC1) variants with warfarin dose in a Hong Kong Chinese patient population.Semantic proximity Read ↗

Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement.Semantic proximity Read ↗

Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation.Semantic proximity Read ↗

A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.Semantic proximity Read ↗

Effect of genetic variants, especially CYP2C9 and VKORC1, on the pharmacology of warfarin.Semantic proximity Read ↗

Interethnic variability of warfarin maintenance requirement is explained by VKORC1 genotype in an Asian population.Semantic proximity Read ↗

Novel regulatory variant detected on the VKORC1 haplotype that is associated with warfarin dose.Semantic proximity Read ↗

The missing association: sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans.Semantic proximity Read ↗

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Integrated analysis of genetic variation and gene expression reveals novel variant for increased warfarin dose requirement in African Americans.Semantic proximity Read ↗

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