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Article

Nuclear receptor gene polymorphisms and warfarin dose requirements in the Quebec Warfarin Cohort.

The pharmacogenomics journal - 1 Apr 2019

Shahabi Payman, Lamothe Félix, Dumas Stéphanie, Rouleau-Mailloux Étienne, Feroz Zada Yassamin, Provost Sylvie, Asselin Geraldine, Mongrain Ian, Valois Diane, Gaulin Marion Marie-Josée, Lemieux Perreault Louis-Philippe, Perreault Sylvie, Dubé Marie-Pierre

Abstract excerpt

Warfarin is primarily metabolized by cytochrome 2C9, encoded by gene CYP2C9. Here, we investigated whether variants in nuclear receptor genes which regulate the expression of CYP2C9 are associated with warfarin response. We used data from 906 warfarin users from the Quebec Warfarin Cohort (QWC) and tested the association of warfarin dose requirement at 3 months following the initiation of therapy in nine nuclear...

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PMID: 29298995
DOI: 10.1038/s41397-017-0005-1
PMCID: PMC6462825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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