Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement.

Blood - 15 Aug 2008

Wang Danxin, Chen Huizi, Momary Kathryn M, Cavallari Larisa H, Johnson Julie A, Sadée Wolfgang

Abstract excerpt

Warfarin dose requirements have been associated with 2 main haplotypes in VKORC1, but the responsible polymorphisms remain unknown. To search for regulatory polymorphisms, we measured allelic mRNA expression of VKORC1 in human liver, heart, and B lymphocytes. The observed 2-fold allelic mRNA expr...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black People
Share to Chromatin
Share to Mixed Function Oxygenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Organ Specificity

Share to Pharmacogenetics

Share to Protein Subunits

Share to Vitamin K Epoxide Reductases

Share to Warfarin

Source

Open in PubMed Open full text

Identifiers

PMID: 18523153
DOI: 10.1182/blood-2008-03-144899
PMCID: PMC2515137

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18523153-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement.PMID 18523153Read ↗

Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.Semantic proximity Read ↗

Novel regulatory variant detected on the VKORC1 haplotype that is associated with warfarin dose.Semantic proximity Read ↗

Integrated analysis of genetic variation and gene expression reveals novel variant for increased warfarin dose requirement in African Americans.Semantic proximity Read ↗

Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.Semantic proximity Read ↗

A vitamin K epoxide reductase-oxidase complex gene polymorphism (-1639G>A) and interindividual variability in the dose-effect of vitamin K antagonists.Semantic proximity Read ↗

Genes affecting warfarin response-interactive or additive?Semantic proximity Read ↗

CYP2C9 promoter variable number tandem repeat polymorphism regulates mRNA expression in human livers.Semantic proximity Read ↗

The c.-1639G>A polymorphism of the VKORC1 gene in Serbian population: retrospective study of the variability in response to oral anticoagulant therapy.Semantic proximity Read ↗

A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity.Semantic proximity Read ↗

Genetic polymorphism of vitamin K epoxide reductase (VKORC1) 1173C>T in a Chinese and a Caucasian population.Semantic proximity Read ↗

The missing association: sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans.Semantic proximity Read ↗

1173C>T polymorphism in VKORC1 modulates the required warfarin dose.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.