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Article

A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response.

PLoS pathogens - 1 Feb 2016

Koday Merika Treants, Nelson Jorgen, Chevalier Aaron, Koday Michael, Kalinoski Hannah, Stewart Lance, Carter Lauren, Nieusma Travis, Lee Peter S, Ward Andrew B, Wilson Ian A, Dagley Ashley, Smee Donald F, Baker David, Fuller Deborah Heydenburg

Abstract excerpt

Broadly neutralizing antibodies targeting a highly conserved region in the hemagglutinin (HA) stem protect against influenza infection. Here, we investigate the protective efficacy of a protein (HB36.6) computationally designed to bind with high affinity to the same region in the HA stem. We show that intranasal delivery of HB36.6 affords protection in mice lethally challenged with diverse strains of influenza...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemagglutinin Glycoproteins, Influenza Virus

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Source

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Identifiers

PMID: 26845438
DOI: 10.1371/journal.ppat.1005409
PMCID: PMC4742065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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