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A small-molecule fusion inhibitor of influenza virus is orally active in mice

7 Mar 2019

Abstract excerpt

Recent characterization of broadly neutralizing antibodies (bnAbs) against influenza virus identified the conserved hemagglutinin (HA) stem as a target for development of universal vaccines and therapeutics. Although several stem bnAbs are being evaluated in clinical trials, antibodies are generally unsuited for oral delivery. Guided by structural knowledge of the interactions and mechanism of anti-stem bnAb...

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PMID: 30846569
DOI: 10.1126/science.aar6221

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