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Article

Computational design of proteins targeting the conserved stem region of influenza hemagglutinin.

Science (New York, N.Y.) - 13 May 2011

Fleishman Sarel J, Whitehead Timothy A, Ekiert Damian C, Dreyfus Cyrille, Corn Jacob E, Strauch Eva-Maria, Wilson Ian A, Baker David

Abstract excerpt

We describe a general computational method for designing proteins that bind a surface patch of interest on a target macromolecule. Favorable interactions between disembodied amino acid residues and the target surface are identified and used to anchor de novo designed interfaces. The method was used to design proteins that bind a conserved surface patch on the stem of the influenza hemagglutinin (HA) from the 1918...

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Share to Hemagglutinin Glycoproteins, Influenza Virus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hydrophobic and Hydrophilic Interactions

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Source

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Identifiers

PMID: 21566186
DOI: 10.1126/science.1202617
PMCID: PMC3164876

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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