Article

Functional, Immunogenetic, and Structural Convergence in Influenza Immunity between Humans and Macaques

2025-02-27

Abstract excerpt

<h4>SUMMARY</h4> Human B cell immunity to the influenza hemagglutinin (HA) stem region, a universal influenza vaccine target, is often stereotyped and immunogenetically restricted, posing challenges for study outside humans. Here, we show that macaques vaccinated with a HA stem immunogen elicit human-like public B cell lineages targeting two major conserved sites of vulnerability, the central stem and anchor epit...

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Literature Corpus work: 9aea75b4-e382-5a35-9e4d-a5f2aee075fa
DOI: 10.1101/2025.02.21.639368

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