Article

The pre-existing human antibody repertoire to computationally optimized influenza H1 hemagglutinin vaccines

2021-10-26

Abstract excerpt

The computationally optimized broadly reactive antigen (COBRA) approach has previously been used to generate hemagglutinin (HA) immunogens for several influenza subtypes that expand vaccine-elicited antibody breadth. As nearly all individuals have pre-existing immunity to influenza viruses, influenza-specific memory B cells will likely be recalled upon COBRA HA vaccination. We determined the epitope specificity an...

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Literature Corpus work: 376532d2-753e-5439-b160-c4cba4f8c3f7
DOI: 10.1101/2021.10.25.465669

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