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Article

Klotho Gene and Selective Serotonin Reuptake Inhibitors: Response to Treatment in Late-Life Major Depressive Disorder.

Molecular neurobiology - 1 Mar 2017

Paroni Giulia, Seripa Davide, Fontana Andrea, D'Onofrio Grazia, Gravina Carolina, Urbano Maria, Addante Filomena, Lozupone Madia, Copetti Massimiliano, Pilotto Alberto, Greco Antonio, Panza Francesco

Abstract excerpt

Klotho protein, encoded by the Klotho gene (KL) at locus 13q12, is an antiaging hormone-like protein playing a pivotal role in cell metabolism homeostasis and associated to longevity and age-related diseases. In particular, altered cell metabolism in central nervous system may influence the behavior of serotoninergic neurons. The role of KL in the response to treatment with selective serotonin reuptake inhibitors...

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PMID: 26843110
DOI: 10.1007/s12035-016-9711-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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