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Article

Pharmacogenetics and the serotonin transporter in late-life depression

12 Nov 2008

Abstract excerpt

BACKGROUND: The etiologies of variable antidepressant response remain elusive. Aging and age-related illness add to the complexity and heterogeneity of late-life depression. The serotonin transporter (5-HTT) is the principal site of initial action for several antidepressants, including serotonin re-uptake inhibitors (SSRIs). The serotonin transporter-linked polymorphic region (5-HTTLPR) is the most widely studied...

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PMID: 19040324
DOI: 10.1517/17425250802560279

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