Article
The association between Single Nucleotide Polymorphisms of Klotho Gene and Mortality in Elderly Men: The MrOS Sweden Study.
Scientific reports - 24 Jun 2020
Wu Ping-Hsun, Westerberg Per-Anton, Kindmark Andreas, Tivesten Åsa, Karlsson Magnus K, Mellström Dan, Ohlsson Claes, Fellström Bengt, Linde Torbjörn, Ljunggren Östen
Abstract excerpt
The Klotho (KL) gene is involved in phosphate homeostasis. Polymorphisms in this gene have been reported to be associated with the risk of cardiovascular disease. Here we used computational tools to predict the damage-associated single nucleotide polymorphisms (SNPs) in the human KL gene. We further investigated the association of SNPs in the KL gene and mortality in the Swedish multicenter prospective...
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