Article
A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density.
Scientific reports - 4 Feb 2016
Tang Ruqi, Wei Yiran, Li Zhiqiang, Chen Haoyan, Miao Qi, Bian Zhaolian, Zhang Haiyan, Wang Qixia, Wang Zhaoyue, Lian Min, Yang Fan, Jiang Xiang, Yang Yue, Li Enling, Seldin Michael F, Gershwin M Eric, Liao Wilson, Shi Yongyong, Ma Xiong
Abstract excerpt
Primary biliary cirrhosis (PBC), a chronic autoimmune liver disease, has been associated with increased incidence of osteoporosis. Intriguingly, two PBC susceptibility loci identified through genome-wide association studies are also involved in bone mineral density (BMD). These observations led us to investigate the genetic variants shared between PBC and BMD. We evaluated 72 genome-wide significant BMD SNPs for...
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