Article
Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density.
Nature genetics - 1 Aug 2009
Thorleifsson Gudmar, Holm Hilma, Edvardsson Vidar, Walters G Bragi, Styrkarsdottir Unnur, Gudbjartsson Daniel F, Sulem Patrick, Halldorsson Bjarni V, de Vegt Femmie, d'Ancona Frank C H, den Heijer Martin, Franzson Leifur, Christiansen Claus, Alexandersen Peter, Rafnar Thorunn, Kristjansson Kristleifur, Sigurdsson Gunnar, Kiemeney Lambertus A, Bodvarsson Magnus, Indridason Olafur S, Palsson Runolfur, Kong Augustine, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
Kidney stone disease is a common condition. To search for sequence variants conferring risk of kidney stones, we conducted a genome-wide association study in 3,773 cases and 42,510 controls from Iceland and The Netherlands. We discovered common, synonymous variants in the CLDN14 gene that associate with kidney stones (OR = 1.25 and P = 4.0 x 10(-12) for rs219780[C]). Approximately 62% of the general population is...
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