Article
Vitamin D-receptor genotypes as independent genetic predictors of decreased bone mineral density in primary biliary cirrhosis.
Gastroenterology - 1 Jan 2000
Springer J E, Cole D E, Rubin L A, Cauch-Dudek K, Harewood L, Evrovski J, Peltekova V D, Heathcote E J
Abstract excerpt
BACKGROUND & AIMS: Hepatic osteodystrophy is a complication of primary biliary cirrhosis (PBC). Allelic polymorphisms of the vitamin D receptor (VDR) gene are related to bone mineral density (BMD) in normal cohorts and those with primary osteoporosis. We sought to establish the prevalence of reduced bone mass in PBC, correlate BMD with VDR gene polymorphisms, and identify risk factors for the development of...
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