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Article

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage.

Nature communications - 4 Feb 2016

Alsafadi Samar, Houy Alexandre, Battistella Aude, Popova Tatiana, Wassef Michel, Henry Emilie, Tirode Franck, Constantinou Angelos, Piperno-Neumann Sophie, Roman-Roman Sergio, Dutertre Martin, Stern Marc-Henri

Abstract excerpt

Hotspot mutations in the spliceosome gene SF3B1 are reported in ∼20% of uveal melanomas. SF3B1 is involved in 3'-splice site (3'ss) recognition during RNA splicing; however, the molecular mechanisms of its mutation have remained unclear. Here we show, using RNA-Seq analyses of uveal melanoma, that the SF3B1(R625/K666) mutation results in deregulated splicing at a subset of junctions, mostly by the use of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26842708
DOI: 10.1038/ncomms10615
PMCID: PMC4743009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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