Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma.

Nature genetics - 1 Feb 2013

Harbour J William, Roberson Elisha D O, Anbunathan Hima, Onken Michael D, Worley Lori A, Bowcock Anne M

Abstract excerpt

Uveal melanoma is the most common primary cancer of the eye and often results in fatal metastasis. Here, we describe mutations occurring exclusively at codon 625 of the SF3B1 gene, encoding splicing factor 3B subunit 1, in low-grade uveal melanomas with good prognosis. Thus, uveal melanoma is among a small group of cancers associated with SF3B1 mutations, and these mutations denote a distinct molecular subset of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Comparative Genomic Hybridization
Share to Kaplan-Meier Estimate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microarray Analysis

Share to Phosphoproteins

Share to Ribonucleoprotein, U2 Small Nuclear

Share to RNA Splicing Factors

Share to Uveal Melanoma

Share to Uveal Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 23313955
DOI: 10.1038/ng.2523
PMCID: PMC3789378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma.PMID 23313955Read ↗

Spliceosome Mutations in Uveal Melanoma.Semantic proximity Read ↗

SF3B1 mutations are associated with alternative splicing in uveal melanoma.Semantic proximity Read ↗

Lack of SF3B1 R625 mutations in cutaneous melanoma.Semantic proximity Read ↗

Rare SF3B1 R625 mutations in cutaneous melanoma.Semantic proximity Read ↗

Uveal Melanomas with SF3B1 Mutations: A Distinct Subclass Associated with Late-Onset Metastases.Semantic proximity Read ↗

[Uveal melanoma, a model disease for splicing alterations and oncogenesis].Semantic proximity Read ↗

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage.Semantic proximity Read ↗

Metastatic uveal melanoma: biology and emerging treatments.Semantic proximity Read ↗

Uveal melanoma hepatic metastases mutation spectrum analysis using targeted next-generation sequencing of 400 cancer genesSemantic proximity Read ↗

Identification of Early-Onset Metastasis in SF3B1 Mutated Uveal MelanomaSemantic proximity Read ↗

Spliceosomal mutation drives melanoma tumorigenesis via lineage-specific RAS activation.Semantic proximity Read ↗

SRSF2 Mutations in Uveal Melanoma: A Preference for In-Frame Deletions?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.