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Article

Spliceosome Mutations in Uveal Melanoma.

International journal of molecular sciences - 15 Dec 2020

Nguyen Josephine Q N, Drabarek Wojtek, Yavuzyigitoglu Serdar, Medico Salsench Eva, Verdijk Robert M, Naus Nicole C, de Klein Annelies, Kiliç Emine, Brosens Erwin

Abstract excerpt

Uveal melanoma (UM) is the most common primary intraocular malignancy of the eye. It has a high metastatic potential and mainly spreads to the liver. Genetics play a vital role in tumor classification and prognostication of UM metastatic disease. One of the driver genes mutated in metastasized UM is subunit 1 of splicing factor 3b (SF3B1), a component of the spliceosome complex. Recurrent mutations in components...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33333932
DOI: 10.3390/ijms21249546
PMCID: PMC7765440

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