Article

Precursor RNA structural patterns at SF3B1 mutation sensitive cryptic 3’ splice sites

2025-02-22

Abstract excerpt

SF3B1 is a core component of the spliceosome involved in branch point recognition and 3’ splice site selection. SF3B1 mutation is common in myelodysplastic syndrome and other blood disorders. The most common mutation in SF3B1 is K700E, a lysine to glutamic acid change within the pre-mRNA interacting heat repeat domain. A hallmark of SF3B1 mutation is an increased use of cryptic 3’ splice sites; however, the proper...

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Identifiers and source

Literature Corpus work: 1c482348-e638-51fe-90cd-6c94a6bdf583
DOI: 10.1101/2025.02.19.638873

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