Article
SF3B1 mutations are associated with alternative splicing in uveal melanoma.
Cancer discovery - 1 Oct 2013
Furney Simon J, Pedersen Malin, Gentien David, Dumont Amaury G, Rapinat Audrey, Desjardins Laurence, Turajlic Samra, Piperno-Neumann Sophie, de la Grange Pierre, Roman-Roman Sergio, Stern Marc-Henri, Marais Richard
Abstract excerpt
UNLABELLED: Uveal melanoma, the most common eye malignancy, causes severe visual morbidity and is fatal in approximately 50% of patients. Primary uveal melanoma can be cured by surgery or radiotherapy, but the metastatic disease is treatment refractory. To understand comprehensively uveal melanoma genetics, we conducted single-nucleotide polymorphism arrays and whole-genome sequencing on 12 primary uveal...
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