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Article

Estimation and partition of heritability in human populations using whole-genome analysis methods.

Annual review of genetics - 1 Jan 2013

Vinkhuyzen Anna A E, Wray Naomi R, Yang Jian, Goddard Michael E, Visscher Peter M

Abstract excerpt

Understanding genetic variation of complex traits in human populations has moved from the quantification of the resemblance between close relatives to the dissection of genetic variation into the contributions of individual genomic loci. However, major questions remain unanswered: How much phenotypic variation is genetic; how much of the genetic variation is additive and can be explained by fitting all genetic...

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PMID: 23988118
DOI: 10.1146/annurev-genet-111212-133258
PMCID: PMC4037293

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