Evaluating the contribution of genetics and familial shared environment to common disease using the UK Biobank.

Abstract excerpt

Genome-wide association studies have detected many loci underlying susceptibility to disease, but most of the genetic factors that contribute to disease susceptibility remain unknown. Here we provide evidence that part of the 'missing heritability' can be explained by an overestimation of heritability. We estimated the heritability of 12 complex human diseases using family history of disease in 1,555,906...

Topics

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• Biological Specimen Banks
• Disease
• Gene-Environment Interaction
• Genome-Wide Association Study
• Models, Genetic