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Article

Improvement of polygenic modeling of blood pressure traits using lifestyle information in the UK Biobank.

Genetics - 9 Jul 2025

Tiezzi Francesco, Goda Khushi, Morgante Fabio

Abstract excerpt

Complex traits are determined by the effects of multiple genetic variants, multiple environmental factors, and potentially their interaction. Predicting complex trait phenotypes from genotypes is a fundamental task in quantitative genetics that was pioneered in agricultural breeding for selection purposes. However, it has recently become important in human genetics. While prediction accuracy for some human...

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PMID: 40365690
DOI: 10.1093/genetics/iyaf089
PMCID: PMC12239206

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