Rapid Evolution of Citrate Utilization by Escherichia coli by Direct Selection Requires citT and dctA.

doi:10.1128/JB.00831-15

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Article

Rapid Evolution of Citrate Utilization by Escherichia coli by Direct Selection Requires citT and dctA.

Journal of bacteriology - 1 Feb 2016

Van Hofwegen Dustin J, Hovde Carolyn J, Minnich Scott A

Abstract excerpt

The isolation of aerobic citrate-utilizing Escherichia coli (Cit(+)) in long-term evolution experiments (LTEE) has been termed a rare, innovative, presumptive speciation event. We hypothesized that direct selection would rapidly yield the same class of E. coli Cit(+) mutants and follow the same genetic trajectory: potentiation, actualization, and refinement. This hypothesis was tested with wild-type E. coli...

Topics

Biological Evolution
Citrates
Culture Media
DNA, Bacterial
Dicarboxylic Acid Transporters
Escherichia coli K12
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Mutation
Organic Anion Transporters
Selection, Genetic
Time Factors

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Identifiers

PMID: 26833416
DOI: 10.1128/JB.00831-15
PMCID: PMC4800869

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