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Article

Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2008

Blount Zachary D, Borland Christina Z, Lenski Richard E

Abstract excerpt

The role of historical contingency in evolution has been much debated, but rarely tested. Twelve initially identical populations of Escherichia coli were founded in 1988 to investigate this issue. They have since evolved in a glucose-limited medium that also contains citrate, which E. coli cannot use as a carbon source under oxic conditions. No population evolved the capacity to exploit citrate for >30,000...

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Identifiers

PMID: 18524956
DOI: 10.1073/pnas.0803151105
PMCID: PMC2430337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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