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Article

Fine-tuning citrate synthase flux potentiates and refines metabolic innovation in the Lenski evolution experiment.

eLife - 14 Oct 2015

Quandt Erik M, Gollihar Jimmy, Blount Zachary D, Ellington Andrew D, Georgiou George, Barrick Jeffrey E

Abstract excerpt

Evolutionary innovations that enable organisms to colonize new ecological niches are rare compared to gradual evolutionary changes in existing traits. We discovered that key mutations in the gltA gene, which encodes citrate synthase (CS), occurred both before and after Escherichia coli gained the ability to grow aerobically on citrate (Cit(+) phenotype) during the Lenski long-term evolution experiment. The first...

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Identifiers

PMID: 26465114
DOI: 10.7554/eLife.09696
PMCID: PMC4718724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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