Article

Medical relevance of common protein-altering variants in GPCR genes across 337,205 individuals in the UK Biobank

2019-12-15

Abstract excerpt

G protein-coupled receptors (GPCRs) drive an array of critical physiological functions and are an important class of drug targets, though a map of which GPCR genetic variants are associated with phenotypic variation is lacking. We performed a phenome-wide association analysis for 269 common protein-altering variants in 156 GPCRs and 275 phenotypes, including disease outcomes and diverse quantitative measurements,...

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Literature Corpus work: f69066f4-eb51-5eac-aabc-66138c111e77
DOI: 10.1101/2019.12.13.876250

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