Article
Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats.
European journal of human genetics : EJHG - 1 Feb 2012
Rask-Andersen Mathias, Jacobsson Josefin A, Moschonis George, Chavan Rohit A, Sikder Md Abu Noman, Allzén Elin, Alsiö Johan, Chrousos George P, Manios Yannis, Fredriksson Robert, Schiöth Helgi B
Abstract excerpt
Genome-wide association studies have shown a strong association of single-nucleotide polymorphisms (SNPs) in the near vicinity of the TMEM18 gene. The effects of the TMEM18-associated variants are more readily observed in children. TMEM18 encodes a 3TM protein, which locates to the nuclear membrane. The functional context of TMEM18 and the effects of its associated variants are as of yet undetermined. To further...
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