Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The signal peptide peptidase SppA is involved in sterol regulatory element-binding protein cleavage and hypoxia adaptation in Aspergillus nidulans.

Molecular microbiology - 1 May 2016

Bat-Ochir Chinbayar, Kwak Jun-Yong, Koh Sun-Ki, Jeon Mee-Hyang, Chung Dawoon, Lee Yin-Won, Chae Suhn-Kee

Abstract excerpt

Using forward genetics, we revealed that the signal peptide peptidase (SPP) SppA, an aspartyl protease involved in regulated intramembrane proteolysis (RIP), is essential for hypoxia adaptation in Aspergillus nidulans, as well as hypoxia-sensitive mutant alleles of a sterol regulatory element-binding protein (SREBP) srbA and the Dsc ubiquitin E3 ligase complex dscA-E. Both null and dead activity [D337A] mutants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Aspartic Acid Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aspergillus nidulans

Share to Endoplasmic Reticulum

Share to Genetic Complementation Test

Share to Oxygen

Share to Protein Processing, Post-Translational

Share to Proteolysis

Source

Identifiers

PMID: 26822492
DOI: 10.1111/mmi.13341

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The signal peptide peptidase SppA is involved in sterol regulatory element-binding protein cleavage and hypoxia adaptation in Aspergillus nidulans.PMID 26822492Read ↗

Identification and Characterization of a Novel Aspergillus fumigatus Rhomboid Family Putative Protease, RbdA, Involved in Hypoxia Sensing and Virulence.Semantic proximity Read ↗

Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast.Semantic proximity Read ↗

RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in <i>Aspergillus fumigatus</i>Semantic proximity Read ↗

Expression and characterization of Drosophila signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease.Semantic proximity Read ↗

The site-2 protease.Semantic proximity Read ↗

Phenotypic and Proteomic Analysis of the Aspergillus fumigatus ΔPrtT, ΔXprG and ΔXprG/ΔPrtT Protease-Deficient MutantsSemantic proximity Read ↗

More Than Just Cleaning: Ubiquitin-Mediated Proteolysis in Fungal PathogenesisSemantic proximity Read ↗

Function of site-2 proteases in bacteria and bacterial pathogens.Semantic proximity Read ↗

A novel family of dehydrin-like proteins is involved in stress response in the human fungal pathogen Aspergillus fumigatus.Semantic proximity Read ↗

The CCAAT-binding complex mediates azole susceptibility of Aspergillus fumigatus by suppressing SrbA expression and cleavage.Semantic proximity Read ↗

Drosophila signal peptidase complex member Spase12 is required for development and cell differentiation.Semantic proximity Read ↗

A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.