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Article

The CCAAT-binding complex mediates azole susceptibility of Aspergillus fumigatus by suppressing SrbA expression and cleavage.

MicrobiologyOpen - 1 Nov 2021

Zhang Chi, Gao Lu, Ren Yiran, Gu Huiyu, Zhang Yuanwei, Lu Ling

Abstract excerpt

In fungal pathogens, the transcription factor SrbA (a sterol regulatory element-binding protein, SREBP) and CBC (CCAAT binding complex) have been reported to regulate azole resistance by competitively binding the TR34 region (34 mer) in the promoter of the drug target gene, erg11A. However, current knowledge about how the SrbA and CBC coordinately mediate erg11A expression remains limited. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34964293
DOI: 10.1002/mbo3.1249
PMCID: PMC8608569

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