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RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in <i>Aspergillus fumigatus</i>

3 Mar 2016

Abstract excerpt

SREBP transcription factors play a critical role in fungal virulence; however, the mechanisms of sterol regulatory element binding protein (SREBP) activation in pathogenic fungi remains ill-defined. Screening of the Neurospora crassa whole-genome deletion collection for genes involved in hypoxia responses identified a gene for an uncharacterized rhomboid protease homolog, rbdB, required for growth under hypoxic...

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PMID: 27303716
DOI: 10.1128/msphere.00035-16

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