Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast.

The Journal of biological chemistry - 12 Jul 2013

Chong Rockie, Espenshade Peter J

Abstract excerpt

Sterol regulatory element-binding proteins (SREBPs) are central regulators of cellular lipid synthesis and homeostasis. Mammalian SREBPs are proteolytically activated and liberated from the membrane by Golgi Site-1 and Site-2 proteases. Fission yeast SREBPs, Sre1 and Sre2, employ a different mechanism that genetically requires the Golgi Dsc E3 ligase complex for cleavage activation. Here, we established Sre2 as a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaerobiosis
Share to Glycine
Share to Leucine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proteolysis

Share to Schizosaccharomyces pombe Proteins

Share to Sterol Regulatory Element Binding Protein 2

Share to Ubiquitin-Conjugating Enzymes

Share to Valosin Containing Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 23729666
DOI: 10.1074/jbc.M113.482224
PMCID: PMC3711301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast.PMID 23729666Read ↗

The signal peptide peptidase SppA is involved in sterol regulatory element-binding protein cleavage and hypoxia adaptation in Aspergillus nidulans.Semantic proximity Read ↗

4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress.Semantic proximity Read ↗

Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster.Semantic proximity Read ↗

Activation of sterol regulatory element-binding protein by the caspase Drice in Drosophila larvae.Semantic proximity Read ↗

The SREBP pathway in Drosophila: regulation by palmitate, not sterols.Semantic proximity Read ↗

Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP.Semantic proximity Read ↗

The site-2 protease.Semantic proximity Read ↗

Identification and Characterization of a Novel Aspergillus fumigatus Rhomboid Family Putative Protease, RbdA, Involved in Hypoxia Sensing and Virulence.Semantic proximity Read ↗

A link between virulence and homeostatic responses to hypoxia during infection by the human fungal pathogen Cryptococcus neoformans.Semantic proximity Read ↗

Cryptococcus neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs.Semantic proximity Read ↗

Dominant missense variants in SREBF2 are associated with complex dermatological, neurological, and skeletal abnormalities.Semantic proximity Read ↗

Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.