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Article

A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors.

Proceedings of the National Academy of Sciences of the United States of America - 21 Dec 1999

Rudner D Z, Fawcett P, Losick R

Abstract excerpt

We present evidence that the sporulation protein SpoIVFB of Bacillus subtilis is a member of a newly recognized family of metalloproteases that have catalytic centers adjacent to or within the membrane. SpoIVFB is required for converting the membrane-associated precursor protein, pro-sigma(K), to the mature and active transcription factor sigma(K) by proteolytic removal of an N-terminal extension of 20 amino...

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Source

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Identifiers

PMID: 10611287
DOI: 10.1073/pnas.96.26.14765
PMCID: PMC24722

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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