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Article

Expression and characterization of Drosophila signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease.

PloS one - 1 Jan 2012

Casso David J, Liu Songmei, Biehs Brian, Kornberg Thomas B

Abstract excerpt

Intramembrane proteases of the Signal Peptide Peptidase (SPP) family play important roles in developmental, metabolic and signaling pathways. Although vertebrates have one SPP and four SPP-like (SPPL) genes, we found that insect genomes encode one Spp and one SppL. Characterization of the Drosophila sppL gene revealed that the predicted SppL protein is a highly conserved structural homolog of the vertebrate SPPL3...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22439002
DOI: 10.1371/journal.pone.0033827
PMCID: PMC3306293

Genes

SPPL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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