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Article

Drosophila signal peptidase complex member Spase12 is required for development and cell differentiation.

PloS one - 1 Jan 2013

Haase Gilbert Erin, Kwak Su-Jin, Chen Rui, Mardon Graeme

Abstract excerpt

It is estimated that half of all proteins expressed in eukaryotic cells are transferred across or into at least one cellular membrane to reach their functional location. Protein translocation into the endoplasmic reticulum (ER) is critical to the subsequent localization of secretory and transmembrane proteins. A vital component of the translocation machinery is the signal peptidase complex (SPC)--which is...

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PMID: 23573290
DOI: 10.1371/journal.pone.0060908
PMCID: PMC3616019

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