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Article

Pharmacologic blockade and genetic deletion of androgen receptor attenuates aortic aneurysm formation.

Journal of vascular surgery - 1 Jun 2016

Davis John P, Salmon Morgan, Pope Nicolas H, Lu Guanyi, Su Gang, Meher Akshaya, Ailawadi Gorav, Upchurch Gilbert R

Abstract excerpt

BACKGROUND: Testosterone is theorized to play a major role in the pathophysiology of abdominal aortic aneurysms (AAAs) because this disease occurs primarily in men. The role of the androgen receptor (AR) in the formation of AAAs has not been well elucidated, and therefore, it is hypothesized that androgen blockade will attenuate experimental aortic aneurysm formation. METHODS: Aortas of 8- to 12-week-old male...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26817611
DOI: 10.1016/j.jvs.2015.11.038
PMCID: PMC4884130

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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