Article
Adenosine 2A receptor modulates inflammation and phenotype in experimental abdominal aortic aneurysms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2013
Bhamidipati Castigliano M, Mehta Gaurav S, Moehle Christopher W, Meher Akshaya K, Su Gang, Vigneshwar Navin G, Barbery Carlos, Sharma Ashish K, Kron Irving L, Laubach Victor E, Owens Gary K, Upchurch Gilbert R, Ailawadi Gorav
Abstract excerpt
Activation of the adenosine 2A receptor (A2AR) reduces inflammation in models of acute injury but contribution in development of chronic abdominal aortic aneurysms (AAAs) is unknown. Elastase perfusion to induce AAA formation in A2AR-knockout (A2ARKO) and C57BL6/J wild-type (WT) mice resulted in nearly 100% larger aneurysms in A2ARKO compared to WT at d 14 (P<0.05), with evidence of greater elastin fragmentation,...
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