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Article

miR-133a Replacement Attenuates Thoracic Aortic Aneurysm in Mice.

Journal of the American Heart Association - 17 Aug 2021

Akerman Adam W, Collins Elizabeth N, Peterson Andrew R, Collins Lauren B, Harrison Jessica K, DeVaughn Amari, Townsend Jaleel M, Vanbuskirk Rebecca L, Riopedre-Maqueira Jessica, Reyes Ailet, Oh Joyce E, Raybuck Charles M, Jones Jeffrey A, Ikonomidis John S

Abstract excerpt

Background Thoracic aortic aneurysms (TAAs) occur because of abnormal remodeling of aortic extracellular matrix and are accompanied by the emergence of proteolytically active myofibroblasts. The microRNA miR-133a regulates cellular phenotypes and is reduced in clinical TAA specimens. This study tested the hypothesis that miR-133a modulates aortic fibroblast phenotype, and overexpression by lentivirus attenuates...

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Share to Aorta, Thoracic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34387094
DOI: 10.1161/JAHA.120.019862
PMCID: PMC8475064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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