Article
ABCG2 loss-of-function polymorphism predicts poor response to allopurinol in patients with gout.
The pharmacogenomics journal - 1 Mar 2017
Roberts R L, Wallace M C, Phipps-Green A J, Topless R, Drake J M, Tan P, Dalbeth N, Merriman T R, Stamp L K
Abstract excerpt
Many patients fail to achieve the recommended serum urate (SU) target (<6 mgdl-1) with allopurinol. The aim of our study was to examine the association of ABCG2 with SU target in response to standard doses of allopurinol using a cohort with confirmed adherence. Good response was defined as SU<6 mgdl-1 on allopurinol ⩽300 mgd-1 and poor response as SU⩾6 mgdl-1 despite allopurinol >300 mgd-1. Adherence was...
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