Association of rare and common genetic variants in MOCOS with inadequate response to allopurinol.

doi:10.1093/rheumatology/keae420

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Article

Association of rare and common genetic variants in MOCOS with inadequate response to allopurinol.

Rheumatology (Oxford, England) - 1 Nov 2024

Fanning Niamh C, Cadzow Murray, Topless Ruth K, Frampton Chris, Dalbeth Nicola, Merriman Tony R, Stamp Lisa K

Abstract excerpt

OBJECTIVES: The minor allele of the common rs2231142 ABCG2 variant predicts inadequate response to allopurinol urate lowering therapy. We hypothesize that additional variants in genes encoding urate transporters and allopurinol-to-oxypurinol metabolic enzymes also predict allopurinol response. METHODS: This study included a subset of participants with gout from the Long-term Allopurinol Safety Study Evaluating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Share to Glucose Transport Proteins, Facilitative

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Identifiers

PMID: 39137147
DOI: 10.1093/rheumatology/keae420
PMCID: PMC11534095

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