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Article

Association between ABCG2 rs2231142 and poor response to allopurinol: replication and meta-analysis.

Rheumatology (Oxford, England) - 1 Apr 2018

Wallace Mary C, Roberts Rebecca L, Nanavati Payal, Miner Jeffrey N, Dalbeth Nicola, Topless Ruth, Merriman Tony R, Stamp Lisa K

Abstract excerpt

Objective: ABCG2 rs2231142 (Q141K) has been reported to be associated with poor response to allopurinol, while there are conflicting data on the association between the genetically independent ABCG2 rs10011796 variant and allopurinol response. The aim of this study was to replicate the association of ABCG2 rs2231142 and rs10011796 with allopurinol response and perform a meta-analysis. Methods: Participants in the...

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Topics

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Share to Allopurinol
Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
Share to DNA
Share to Genetic Predisposition to Disease
Share to Gout
Share to Gout Suppressants
Share to Neoplasm Proteins
Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 29342288
DOI: 10.1093/rheumatology/kex467

Genes

ABCG2

Variants

rs2231142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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