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Article

Mutation load in melanoma is affected by MC1R genotype.

Pigment cell & melanoma research - 1 Mar 2017

Johansson Peter A, Pritchard Antonia L, Patch Ann-Marie, Wilmott James S, Pearson John V, Waddell Nicola, Scolyer Richard A, Mann Graham J, Hayward Nicholas K

Abstract excerpt

Whole-genome sequencing of matched germline and tumour pairs in a well-characterized cohort of melanoma patients allowed investigation of associations between melanoma body site, age at melanoma onset and MC1R variant status with overall mutation burden and specific base pair changes observed in the corresponding melanoma. We observed statistically significant associations between mutation burden in melanoma and...

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PMID: 28024115
DOI: 10.1111/pcmr.12571

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