Article
NRAS and BRAF mutations in cutaneous melanoma and the association with MC1R genotype: findings from Spanish and Austrian populations.
The Journal of investigative dermatology - 1 Apr 2013
Hacker Elke, Nagore Eduardo, Cerroni Lorenzo, Woods Susan L, Hayward Nicholas K, Chapman Brett, Montgomery Grant W, Soyer H Peter, Whiteman David C
Abstract excerpt
There is increasing epidemiologic and molecular evidence that cutaneous melanomas arise through multiple causal pathways. To further define the pathways to melanoma, we explored the relationship between germline and somatic mutations in a series of melanomas collected from 134 Spanish and 241 Austrian patients. Tumor samples were analyzed for melanocortin-1 receptor (MC1R) variants and mutations in the BRAF and...
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