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Article

Human Determinants and the Role of Melanocortin-1 Receptor Variants in Melanoma Risk Independent of UV Radiation Exposure.

JAMA dermatology - 1 Jul 2016

Wendt Judith, Rauscher Sabine, Burgstaller-Muehlbacher Sebastian, Fae Ingrid, Fischer Gottfried, Pehamberger Hubert, Okamoto Ichiro

Abstract excerpt

IMPORTANCE: Despite the unquestioned relationship of UV radiation (UVR) exposure and melanoma development, UVR-independent development of melanoma has only recently been described in mice. These findings in mice highlight the importance of the genetic background of the host and could be relevant for preventive measures in humans. OBJECTIVE: To study the role of the melanocortin-1 receptor (MC1R) and melanoma risk...

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Identifiers

PMID: 27050141
DOI: 10.1001/jamadermatol.2016.0050

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