A genetic and physical study of the interdomain linker of E. Coli AraC protein--a trans-subunit communication pathway.

Abstract excerpt

Genetic experiments with full length AraC and biophysical experiments with its dimerization domain plus linker suggest that arabinose binding to the dimerization domain changes the properties of the inter-domain linker which connects the dimerization domain to the DNA binding domain via interactions that do not depend on the DNA binding domain. Normal AraC function was found to tolerate considerable linker...

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