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Article

DNA bending by AraC: a negative mutant.

Journal of bacteriology - 1 Aug 1998

Saviola B, Seabold R R, Schleif R F

Abstract excerpt

We sought a mutation in the DNA binding domain of the arabinose operon regulatory protein, AraC, of Escherichia coli that allows the protein to bind DNA normally but not activate transcription. The mutation was isolated by mutagenizing a plasmid overproducing a chimeric leucine zipper-AraC DNA binding domain and screening for proteins that were trans dominant negative with regard to wild-type AraC protein. The...

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Identifiers

PMID: 9696773
DOI: 10.1128/JB.180.16.4227-4232.1998
PMCID: PMC107421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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DNA bending by AraC: a negative mutant.PMID 9696773Read ↗

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Activation of ara operons by a truncated AraC protein does not require inducer.Semantic proximity Read ↗

Hemiplegic mutations in AraC protein.Semantic proximity Read ↗

Elucidating residue roles in engineered variants of AraC regulatory protein.Semantic proximity Read ↗

AraC regulatory protein mutants with altered effector specificity.Semantic proximity Read ↗

Mutations in the araC gene of Salmonella typhimurium LT2 which affect both activator and auto-regulatory functions of the AraC protein.Semantic proximity Read ↗

Understanding the basis of a class of paradoxical mutations in AraC through simulations.Semantic proximity Read ↗

Probing key DNA contacts in AraR-mediated transcriptional repression of the Bacillus subtilis arabinose regulon.Semantic proximity Read ↗

Allosteric regulation within the highly interconnected structural scaffold of AraC/XylS homologs tolerates a wide range of amino acid changes.Semantic proximity Read ↗

Computational and experimental investigation of constitutive behavior in AraC.Semantic proximity Read ↗

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