Article
Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness.
American journal of respiratory and critical care medicine - 15 Nov 2009
Koppelman Gerard H, Meyers Deborah A, Howard Timothy D, Zheng S Lilly, Hawkins Greg A, Ampleford Elizabeth J, Xu Jianfeng, Koning Henk, Bruinenberg Marcel, Nolte Ilja M, van Diemen Cleo C, Boezen H Marike, Timens Wim, Whittaker Paul A, Stine O Colin, Barton Sheila J, Holloway John W, Holgate Stephen T, Graves Penelope E, Martinez Fernando D, van Oosterhout Antoon J, Bleecker Eugene R, Postma Dirkje S
Abstract excerpt
RATIONALE: Asthma is a chronic inflammatory airway disease that affects more than 300 million individuals worldwide. Asthma is caused by interaction of genetic and environmental factors. Bronchial hyperresponsiveness (BHR) is a hallmark of asthma and results from increased sensitivity of the airw...
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