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Article

Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1.

Nature - 29 Jul 2004

Sayah David M, Sokolskaja Elena, Berthoux Lionel, Luban Jeremy

Abstract excerpt

In Old World primates, TRIM5-alpha confers a potent block to human immunodeficiency virus type 1 (HIV-1) infection that acts after virus entry into cells. Cyclophilin A (CypA) binding to viral capsid protects HIV-1 from a similar activity in human cells. Among New World primates, only owl monkeys exhibit post-entry restriction of HIV-1 (ref. 1). Paradoxically, the barrier to HIV-1 in owl monkey cells is released...

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Source

Identifiers

PMID: 15243629
DOI: 10.1038/nature02777

Genes

TRIM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1.PMID 15243629Read ↗

Requirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1.Semantic proximity Read ↗

Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate speciesSemantic proximity Read ↗

Independent evolution of an antiviral TRIMCyp in rhesus macaquesSemantic proximity Read ↗

Evolution of a TRIM5-CypA splice isoform in old world monkeys.Semantic proximity Read ↗

Cyclophilin A protects HIV-1 from restriction by human TRIM5αSemantic proximity Read ↗

Birth, decay, and reconstruction of an ancient <i>TRIMCyp</i> gene fusion in primate genomesSemantic proximity Read ↗

A novel fusion gene, TRIM5-Cyclophilin A in the pig-tailed macaque determines its susceptibility to HIV-1 infectionSemantic proximity Read ↗

TRIMCyp expression in Old World primates <i>Macaca nemestrina</i> and <i>Macaca fascicularis</i>Semantic proximity Read ↗

Naturally Occurring Capsid Substitutions Render HIV-1 Cyclophilin A Independent in Human Cells and TRIM-cyclophilin-resistant in Owl Monkey CellsSemantic proximity Read ↗

Proteasome Inhibition Reveals that a Functional Preintegration Complex Intermediate Can Be Generated during Restriction by Diverse TRIM5 ProteinsSemantic proximity Read ↗

Novel mutant human immunodeficiency virus type 1 strains with high degree of resistance to cynomolgus macaque TRIMCyp generated by random mutagenesis.Semantic proximity Read ↗

Lentiviral Gene Therapy Against Human Immunodeficiency Virus Type 1, Using a Novel Human TRIM21-Cyclophilin A Restriction FactorSemantic proximity Read ↗

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