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Article

TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1.

The Journal of general virology - 1 Jun 2013

Saito Akatsuki, Nomaguchi Masako, Kono Ken, Iwatani Yasumasa, Yokoyama Masaru, Yasutomi Yasuhiro, Sato Hironori, Shioda Tatsuo, Sugiura Wataru, Matano Tetsuro, Adachi Akio, Nakayama Emi E, Akari Hirofumi

Abstract excerpt

TRIM5α restricts human immunodeficiency virus type 1 (HIV-1) infection in cynomolgus monkey (CM) cells. We previously reported that a TRIMCyp allele expressing TRIM5-cyclophilin A fusion protein was frequently found in CMs. Here, we examined the influence of TRIM5 gene variation on the susceptibility of CMs to a monkey-tropic HIV-1 derivative (HIV-1mt) and found that TRIMCyp homozygotes were highly susceptible to...

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Identifiers

PMID: 23486671
DOI: 10.1099/vir.0.050252-0

Genes

TRIM5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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